Humulene, as α-humulene, is found in many plants, and is also called α-caryophyllene. It can inhibit fruit fly mating, thereby providing some defence to plants. Traditionally humulene containing plants have been used for the treatment of depression, insomnia, anxiety and digestive disorders. Humulene and its derivatives have shown value in modern science as:1,2

  • Anti-inflammatory (comparative to dexamethasone systemically)
  • Anti-neoplastic
  • Anti-allergy
  • Antibacterial


  1. Russo, E. & Marcu, J. Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads. Advances in Pharmacology 80, 67-134 (2017). doi:10.1016/bs.apha.2017.03.004[]
  2. Baron, E. Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science. Headache 58(7), 1139-1186 (2018). doi:10.1111/head.13345[]
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